| 摘要 |
A new and improved process for making phenylisopropylurea derivatives having the formula: <IMAGE> wherein R1 is selected from hydrogen, halogen, alkyl, alkenyl, haloalkyl or R2 groups and R2 is selected from phenyl, alkyl-substituted phenyl alkoxy-substituted phenyl or haloalkyl-substituted phenyl is disclosed. The process comprises reacting a substituted urea of the formula: <IMAGE> with an alkenyl aromatic compound of the formula: <IMAGE> in a polar aprotic solvent, in the presence of an acid catalyst, preferably, sulfuric acid, substituted sulfonic acids or Lewis acids, and stirring the reaction mixture at a temperature of about 20 DEG to 80 DEG C. until formation of the precipitated phenylisopropylurea derivative is substantially complete.
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