NYA KOLESTEROLSYNTESEN INHIBERANDE TRANS-6-/2-(SUBSTITUERADE PYRROL-1-YL)ALKYL/-PYRAN-2-ONER OCH FOERFARANDE FOER DERAS FRAMSTAELLNING.

摘要

6-[2-(Substituted-pyrrol-1-yl)alkyl]pyran-2-ones and the corresponding ring-opened hydroxy-acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMG-CoA reductase), and are thus useful hypolipidemic and hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of treatment employing such pharmaceutical compositions are also disclosed.