7.alpha.-ACYLTHIO-15,16-METHYLENE-3-OXO-17.alpha.-PREGNA-1,4- DIENE-21,17-CARBOLACTONES, PROCESS FOR THE PREPARATION THEREOF, AND USE THEREOF AS MEDICINAL AGENTS

摘要

7.alpha.-acylthio-15,16-methylene-3-oxo-17.alpha.-pregna-1,4-diene-21,17-carbolactones of the formula < IMG > wherein the 15,16-methylene group can be in the .alpha.or .beta.-configuration, and R is a lower alkyl residue, have altialdosterone activity. They are prepared from corresponding .DELTA.4unsaturated compounds by chemical or microbiological 1,2-dehydrogenation.