发明名称 |
PRODUCTION OF HUMAN WHITE CORPUSCLE INTERFERON ALPHA-2 |
摘要 |
A method for producing human leukocyte interferon alpha-2 resides in that there is carried out submerged cultivation of a producer strain Pseudomonas species VG-84 carrying a plasmid pVG3 with an inserted gene of human leukocyte interferon alpha-2, said strain being deposited in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1742; said strain being cultivated in a nutrient medium, containing the sources of carbon and nitrogen, mineral salts and growth stimulants, under aeration in the presence of antibiotics, i.e., streptomycin or tetracycline, or a mixture of both, followed by isolation and purification of the end product. |
申请公布号 |
JPS6156093(A) |
申请公布日期 |
1986.03.20 |
申请号 |
JP19850152567 |
申请日期 |
1985.07.12 |
申请人 |
FUSESO N ISUSUREDO INST GENETEIKI I SEREKUTSUII PUROMIISHIRENNIIFU MIKUROORUGANIZUMOFU FUNIIGENETEIKA;INSUCHI BIOORUGANICHIESUKOI CHEM IMENI M M SHIEMIYAKINA AN SSR |
发明人 |
URAJIMIIRU GEORUGIEBICHI DEBABOFU;YURI DOMITORIEBICHI TSUSHIGANKOFU;ANDOREI YURIEBICHI CHISUTOSERUDOFU;EFUGENI DABIDOBICHI SUBERUDOROFU;RARA SEMENOFUNA IZOTOBA;SERUGEI BIKUTOROBICHI KOSUTOROFU;BIKUTORU EMIRIEBICHI SUTERUKIN;URAJIMIIRU PAFUROBICHI KUZUNETSUSOFU;SERUGEI BASHIRIEBICHI BERUYAEFU;GARINA SERUGEEFUNA MONASUTEIRUSUKAYA;IRINA SERUGEEFUNA SAROMATEINA;GURIGORI MIHAIROBICHI DORUGANOFU;SERUGEI GAGIKOBICHI ARUSENIAN;SERUGEI ANATORIEBICHI TSUSAREKU;YURI IBANOBICHI KOZURAFU;AREKISANDORU YAKOFUREBICHI SUTORONGIN;FUSEBORODO IBANOBICHI OGARUKOFU;YURI ANATORIEBICHI OFUCHINNIKOFU |
分类号 |
C12N15/09;A61K38/21;C07K14/56;C12N15/78;C12P21/00;C12R1/38 |
主分类号 |
C12N15/09 |
代理机构 |
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