Isoindolinone derivatives, production and use thereof.

摘要

A compound of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="23" wi="47" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein X us hydrogen, halogen or nitro; Ar is phenyl or naphthyridinyl which may optionally be substituted; and either one of Z<Sup>1</Sup> and Z<Sup>2</Sup> is hydrogen and the other is lower alkanoyloxy or hydroxy, each of Z<Sup>1</Sup> and Z<Sup>2</Sup> is lower alkoxy, or Z<Sup>1</Sup> and Z<Sup>2</Sup> combinedly represent hydroxyimino, oxo or a group of the formyla:
<Chemistry id="chema02" num="0002"><Image id="ia02" he="12" wi="17" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>in which Y is oxygen or sulfur and A is a branched or unbranched lower alkylene chain; and a salt thereof, act on the central nervous system but are weak in adverse effects such as hypnotic and muscle relaxant effects.