| 摘要 |
<p>Antiinflammatory activity is exhibited by new steroids having the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="36" wi="63" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and the 1,2-dehydro derivatives thereof, wherein R, is alkyl, mono-, di- or trifluoroalkyl,
<Chemistry id="chema02" num="0002"><Image id="ia02" he="12" wi="35" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>aryl or alkylthioalkyl, wherein R<Sub>6</Sub> is alkyl or aryl and m is 1, 2, 3 or 4;
<Chemistry id="chema03" num="0003"><Image id="ia03" he="14" wi="85" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sub>7</Sub>, R<Sub>8</Sub> and R<Sub>9</Sub> are each independently hydrogen or alkyl of 1 to 4 carbon atoms; R<Sub>3</Sub> is carbonyl or β-hydroxymethylene; R<Sub>4</Sub> is hydrogen or halogen; R<Sub>5</Sub> is hydrogen, methyl or fluorine; and n is 0, 1 or 2; with the proviso that if R<Sub>1</Sub> is alkylthioalkyl, n is 0.</p> |
