发明名称 |
Thieno and furopyridinium-substituted cephalosporins |
摘要 |
Cephalosporin compounds substituted in the 7-position by a 2-(5- or 6-membered heterocyclic)-2-oximinoacetylamino group and in the 3-position with a thienopyridinium methyl group or a furopyridinium methyl group are broad spectrum antibiotics highly effective in combating bacterial infections of gram-negative and gram-positive microorganisms. The cephalosporins are best prepared by reacting a silylated 7-[2-(heterocyclic)-2-oximinoacetylamino]-3-iodomethyl-3-cephem-4-carb oxylic acid with the thienopyridine or the furopyridine. Pharmaceutical formulations comprising a compound of the invention and a method for treating bacterial infections comprising their use are also provided.
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申请公布号 |
US4577014(A) |
申请公布日期 |
1986.03.18 |
申请号 |
US19840679514 |
申请日期 |
1984.12.07 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
LUNN, WILLIAM H. W.;VASILEFF, ROBERT T. |
分类号 |
C07D307/46;C07D307/54;C07D491/04;C07D495/04;C07D501/38;(IPC1-7):C07D501/38;A61K31/545 |
主分类号 |
C07D307/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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