PROPENONE DERIVATIVE AND COMPOSITION

摘要

NEW MATERIAL:The compound of formula I [A is single bond or CH2; R<1> and R<2> are 1-5C alkyl, (substituted) phenyl, (substituted) 5- or 6-membered heterocyclic group, or (substituted) nitrogen-containing condensed heterocyclic group; R is 1-5C alkylidene or (substituted) phenyl-1-5C alkylidene] or its acid addition salt. EXAMPLE:1-(4-Phenylphenyl)-2-(1H-1,2,4-triazol-1-yl)-2-propen-1-one. USE:Pharmaceuticals, animal drugs or agricultural chemicals. Useful as an antimycotic agent, antiulcer agent, cardiotonic, and (agricultural) fungicide. PREPARATION:The compound of formula I wherein R<3> is methylene can be prepared e.g. by reacting the ketone of formula II with bis(dimethylamino)methane and acetic anhydride in a solvent or in the absence of solvent at 0-80 deg.C, preferably <=50 deg.C for several min - several hr.