| 摘要 |
NEW MATERIAL:The compound of formula I (R1 is amino which may be substituted with lower alkoxy or lower alkyl R2-R4 are H or methyl; R5 and R6 are H, lower alkyl, lower alkenyl or together with adjacent N form a ring; n is 0 or 1) and its acid addition salt. EXAMPLE:2-Methoxy-4-piperidinoacetylaminobenzoic acid methyl ester. USE:It has excellent antiarrhythmic action and local anesthetic action, and is useful as a remedy and preventive for extra-sistole, ventricular arrhythmia, paroxysmal tachycardia, etc., and a preventive for arrhythmia accompanying to opration and anesthetic. PREPARATION:The compound of formula I can be prepared by reacting the halide of formula II (X is halogen) with the amine of formula III in the absence or presence of solvent (e.g. water, methanol, etc.) at room temperature -200 deg.C. |
