| 摘要 |
<p>A single-chain plasminogen activator and a double-chain plasminogen activator obtained from a tissue cultured liquor of human normal tissue derived cells and having the following properties: a) molecular weight measured by gel filtration: 63,000 +/- 10,000, b) isoelectric point: 7.0 - 8.5, c) affinity to fibrin: present, d) affinity to concanavalin A: present, e) optimum pH: 7 - 9.5, f) performance on reduction treatment: (1) single-chain structure: substantially does not decompose; (2) double-chain structure: decomposes, and g) hydrolysis activity on synthetic substrates: <IMAGE> process for the production of the aforesaid plasminogen activators; and thrombolytic compositions containing the aforesaid plasminogen activators as an active ingredient are disclosed.</p> |
