| 摘要 |
A long-acting formulation of cefaclor, comprising a mixture of a non-enteric coating component of cefaclor to serve as a rapid-release component with an enteric coated component of cefaclor to serve as a slow-release component at a ratio of about 4:6 respectively based on potency of cefaclor wherein said non-enteric coated component contains at least one additive selected from lactose, sucrose, D-mannitol, corn starch, wheat starch and low-substituted hydroxypropylcellulose in an amount of up to 75% weight based on the whole - non-enteric coated component and said enteric coated component contains at least one additive selected from lactose, sucrose, D-mannitol, corn starch, wheat starch and low-substituted hydroxypropylcellulose in an amount of up to 75% weight based on the whole enteric-coated component, and an enteric-coating which is a film soluble in the pH range 5.0 to 7.0. - (24pp) EPAB- EP-129382 B A long-acting formulation of cefaclor, comprising a mixture of a non-enteric coating component of cefaclor to serve as a rapid-release component with an enteric coated component of cefaclor to serve as a slow-release component at a ratio of about 4:6 respectively based on potency of cefaclor wherein said non-enteric coated component contains at least one additive selected from lactose, sucrose, D-mannitol, corn starch, wheat starch and low-substituted hydroxypropylcellulose in an amount of up to 75% weight based on the whole non-enteric coated component and said enteric coated component contains at least one additive selected from lactose, sucrose, D-mannitol, corn starch, wheat starch and low-substituted hydroxypropylcellulose in an amount of up to 75% weight based on the whole enteric-coated component, and an enteric-coating which is a film soluble in the pH range 5.0 to 7.0. (24pp) GBAB- GB2141342 B A long-acting formulation of cefaclor which comprises both a rapid-release cefaclor component which dissolves rapidly in the stomach and a slow-release cefaclor component which is insoluble in the acid medium of the stomach but rapidly released in the upper portion of the small intestine at pH 5-7 in a ratio of 3:7 to 5:5 based upon cefaclor potency, the former component being formulated to give a maximum blood level of cefaclor rapidly and the latter within a period of 3 to 7 hours after administration. USAB- US4713247 A Pharmaceutical compsn. comprises 3-chloro-7-D- (2-phenylglycylamino) -3-cephem-4-carboxylic acid monohydrate, "Ceflaclor", as the active component, dispersed with binder and coated with a slow release agent; mixed with a similar compsn. coated with a rapidrelease agent, so that the ratio of slow release compsn. to fast release compsn is about 6:4. Carbohydrates e.g. lactose, sucrose, D-mannitol, corn or wheat starch, hydroxypropyl-cellulose or their mixts are carriers (up to 75 wt%), but the slow release component has an enteric coating film (pref. a copolymer of Me methacrylate and methacrylic acid) which dissolves at pH 5-7.
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