A METHOD FOR TREATING FIXED NATURAL TISSUE FOR PREVENTING CALCIFICATION AND DETERIORATION OF PROPERTIES ON IMPLANTATION

摘要

Porcine valve cusp tissue and bovine pericardial tissue useful in the fabrication of prosethetic heart valves for implantation in humans, characterized, in the case of porcine valve cusp tissue, by having an average degree of calcification of less than 1.0 mu g Ca<+><+>/mg tissue after 8 weeks implantation in a Sprague-Dawley rat test. In the case of bovine pericardia tissue, average calcification is less than 2.5 microg. after 8 weeks. The fixed natural tissue intended for implantation in a living body is contacted with an aqueous solution of a water soluble salt of C7-18 alkyl sulfate, such as sodium dodecyl sulfate.