Gram-negative bacterial endotoxin blocking monoclonal antibodies and cells producing the same and formulations containing the same, and the production of all thereof.

摘要

Antibodies whose population is substantially homogeneous are described which bind to determinants defined by the lipid A portions of the cell wall lipopolysaccharides of E. coli Rc mutants and Salmonella Re mutants and neutralize gram-negative bacterial endotoxin. Human IgM embodiments of the antibodies are exemplified. The antibodies are useful for treating bacteremia or sepsis by parenteral administration.