发明名称 |
Water-soluble formulations of m-AMSA with pyroglutamic acid |
摘要 |
This invention concerns novel water-soluble salts and compositions of the antitumor agent 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA). More particularly, there are provided (1) the mono- and dipyroglutamate salts of m-AMSA and (2) compositions of m-AMSA with pyroglutamic acid. The novel salts and compositions provided enable m-AMSA to be administered as an aqueous solution without the necessity of using dimethylacetamide as a pharmaceutical vehicle.
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申请公布号 |
US4575509(A) |
申请公布日期 |
1986.03.11 |
申请号 |
US19840631965 |
申请日期 |
1984.07.18 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
CHEN, JIVN-REN;SHINAL, EDWARD C. |
分类号 |
A61K31/435;C07D207/28;C07D219/10;(IPC1-7):A61K31/47 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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