Use of xanthine and thioxanthine derivatives for the preparation of medicaments.

摘要

A method for the treatment and/or prophylaxis of cerebrovascular disorders and/or disorders associated with cerebral senility in mammals, such as humans, which comprises administering to the mammal in need of such treatment and/or prophylaxis an effective and/or prophylactic amount of a compound of formula (I):
<Chemistry id="chema01" num="0001"><Image id="ia01" he="33" wi="49" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wehrein
<UnorderedLists id="ula01" listStyle="none"><ListItem>(i) R, is a group -X-CO-CH<Sub>3</Sub> where X is a hydrocarbon radical having up to 4 carbon atoms which may be substituted by a methyl group. R<Sub>2</Sub> and R<Sub>3</Sub>. which may be the same or different, each represents a straight-chain or branched-chain alkyl radical of 2 to 6 carbon atoms, or a cyclohexyl, alkoxyalkyl or hydroxyalkyl radical, and Y and Z each represent oxygen;</ListItem><ListItem>(ii) R, is a group -CH<Sub>2</Sub>(OR<Sub>4</Sub>)(OR<Sub>5</Sub>)CH<Sub>3</Sub> wherein R<Sub>4</Sub> is an alkyl radical of 1 to 4 carbon atoms and R, is an alkyl radical of 1 to 4 carbon atoms or R<Sub>4</Sub> is linked to R<Sub>5</Sub> so that the OR. and OR<Sub>5</Sub> moieties and the carbon atoms to which they are attached form a 1,3-dioxacyclohexa-2,2-diyl,1,3-dioxacyclo- penta-2,2-diyl or 1,3-dioxacyclohepta-2,2-diyl diradical, R<Sub>2</Sub> and R<Sub>3</Sub> are the same or different and are each an alkyl radical of 1 to 4 carbon atoms, and Y and Z each represent oxygen;</ListItem><ListItem>(iii) R' is a group -CH<Sub>2</Sub>COCH<Sub>3</Sub> R<Sub>2</Sub> is an alkyl radical of 1 to 6 carbon atoms, R<Sub>3</Sub> is an alkyl radical of 1 to 6 carbon atoms, Z is sulphur and Y is oxygen or sulphur;</ListItem><ListItem>(iv) R, is a group -(CH<Sub>2</Sub>)<Sub>n</Sub>COCH<Sub>3</Sub> where n is 1 or 2, one of R<Sub>2</Sub> and R<Sub>3</Sub> is an alkyl radical of 1 to 6 carbon atoms and the other is an alkyl radical of 2 to 6 carbon atoms, Z is oxygen and Y is sulphur; or</ListItem><ListItem>(v) R, is a group -CHZCOCH<Sub>3</Sub> R<Sub>2</Sub> is an alkyl radical of 1 to 4 carbon atoms, R<Sub>3</Sub> is a group CH<Sub>3</Sub>CO(CH<Sub>2</Sub>)<Sub>4 </Sub>-, and Y and Z each represent oxygen.</ListItem></UnorderedLists>