N GAMMA-SUBSTITUTED HISTIDINE DERIVATIVE, MANUFACTURE AND MANUFACTURE OF HISTIDINE ANALOGUE PROTEIN DERIVATIVE AND ENZYME DERIVATIVE

摘要

A process is disclosed for the preparation of new N tau -substituted histidine derivatives of the general formula (1) According to the process, a histidine derivative of the general formula (2) is reacted with phosgene, and the resultant product is then alkylated and thereafter hydrolyzed with an acid. The products obtained by the process are highly useful for preparation of histidine-analogous proteins and enzymes.