| 摘要 |
<p>Substd. 6-vinyl-(3(2H)-pyridazinone deriv. cpds. and their 4,5-dihydro derivs. of formula (I). In (I) R1, R2=H or 1-4C alkyl; R3=H, 1-4C alkyl or phenyl; dotted line denotes C-C single or double bond; A=unsubstd. phenyl; phenyl substd. by the residue -NH-CO-CHR4R5; phenyl, NH2, 1-4C alkylamino, 1-4C dialkylamino, 1-3C acyloxy, OH, CF3, 1-3C alkoxy, phenoxy, COOH, 1-4C alkoxycarbonyl, CN and NO2; phenyl substd. by a gp. Z; or a 5-or 6-membered heteroaromatic ring, linked through one of its C-atoms, contg. 1-3 hetero atoms selected from N (including the N-oxides), O and S, the heteroaromatic ring opt. carrying 1-2 substits. selected from halogen, CN, CH2OH, OH, COOH, carbamoyl, 1-4C alkyl, 1-4C alkoxy (1-4C alkoxy) carbonyl, 1-4C alkyl carbamoyl or di(1-4C alkyl) carbamoyl, or a heterocyclic residue Z, or being fused with a benzene ring; R4=H, 1-6C alkyl or 2-6C alkenyl; or R5=H, 1-3C alkyl, halogen, OH, 1-3C alkoxy, acetoxy, COOH, (1-3C alkoxy) carbonyl, CN or methanesulphonyloxy); or R4,R5 =2-6C alkylene; Z=satd. partially satd. or aromatic 5- or 6-membered N-heterocycle which opt. contains 1-3 additional heteroatoms selected from O, N and S and which is opt. substd. by 1-3 1-4C alkyl residues (2 of which may be linked so as to form an alkylene bridge) or which is substd. by phenyl or fused with a benzene ring, Z being linked through its ring N-atom; with the exception of cpds. in which A is phenyl, p-tolyl 4-methoxyphenyl or an opt. substd. pyridine residue when R1 and R2 are both H and R3 is H or alkyl.</p> |
