| 摘要 |
<p>Cpds. of the formula (I) and their acid addition salts are new, (where R is H or (1-4C)alkyk; m is 0 or 1; n is 4 or 5). In an example, mixture of 6-chloro-7,8,9,10 -tetrahydro-1,2,4 -triazolo(3,4-a)phthalazine (5.0g), 1-(2-aminoethyl) pyrrolidine (10.0g) and 2-methoxyethanol (50 ml) was refluxed for 15 hrs., concentrated, and partitioned between CH2Cl2 and satd. aq. NaHCO3 soln. The organic layer was dried, concentrated, triturated with ether and filtered to give 6-(2-(1-pyrrolidinyl) ethylamino)-7,8,9,10 -tetrahydro-1,2,4-triazolo (3,4-a)phthalazine (m.pt. 160-162 deg. C). (0/0) EPAB- EP-104506 B A compound of formula (I)wherein R is hydrogen or alkyl of 1-4 carbon atoms; m is 0 or 1; and n is 4 or 5; and the pharmaceutically acceptable acid addition salts thereof. - (12pp) USAB- US4487930 A 6-((Cyclic amino)alkoxyamino) -tetrahydrotriazolo (3,4-a)phthalazine cpds. of formula (I) and their salts are new. In the formula, R is H or 1-4C alkyl m is 0 or 1 n is 4 or 5. The cpds. can be prepd. by reacting a 6-halo 7,8,9,10-tetrahydro -1,2,4-triazolo (3,4-a)phthalazine with an amine of formula (II).</p> |
