| 摘要 |
<p>The invention relates to renin inhibiting compounds of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="17" wi="85" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>
wherein A is an N-protecting group; n is 0 or 1; B is hydrogen, hydroxy NH, loweralkyl or arylalkyl; with the proviso that when A is an N-protecting group, B is NH and when n is 0, B is hydrogen, hydroxy, loweralkyl or arylalkyl; R,, R<Sub>3</Sub> and R<Sub>5</Sub> are loweralkyl or hydrophilic, lipophilic or aromatic amino acid side chains and may be the same or different; R<Sub>2</Sub>, R<Sub>4</Sub>, R<Sub>7</Sub>, R<Sub>8</Sub> and R<Sub>9 </Sub>are hydrogen or loweralkyl and may be the same or different; X is CH<Sub>2</Sub>; R<Sub>B</Sub> is loweralkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl; and X and R<Sub>6</Sub> when taken together may be a vinylic group.</p> |
