| 摘要 |
The invention provides amino acid-containing therapeutic compound having the formula:… K-His-Trp-Ser-Tyr-M-Q-Arg-Pro-T, wherein… K is N-Acetyl-Sarcosine or pGlu;… M is D-Phe, D-Trp, D- beta -Naphthylalanine, or… D-4-X-Phe, wherein X is OH, F, Cl, Br, or Me;… Q is Leu, Phe, 4-X-Phe, Trp, or beta -Naphthylamine (wherein X is OH, F, Cl, Br, or Me), or an N-Me derivative thereof; and… T is Gly-NH2, NHCH3, NHCH2CH3, or NHCH2CH2CH3;… provided that, when Q is Leu or N-Me-Leu, K cannot be pGlu;… or a pharmaceutically acceptable salt thereof. |
