NOVEL AMIDINE COMPOUNDS

摘要

PCT No. PCT/JP85/00392 Sec. 371 Date Feb. 24, 1986 Sec. 102(e) Date Feb. 24, 1986 PCT Filed Jul. 12, 1985 PCT Pub. No. WO86/00893 PCT Pub. Date Feb. 13, 1986.Amidine compounds of formula (I) (I) and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin and anti-complement agents which may be administered orally. These amidine compounds can be produced by the reaction between a carboxylic acid compound of formula (II) (II) or a reactive intermediate thereof and 6-amidino-2-naphthol of formula (III) (III) or preferably an acid addition salt thereof.