| 摘要 |
<p>NEW MATERIAL:A compound shown by the formula I {R<1> is lower alkyl; X is COOH, hydroxymethyl, -CO2R<2>[R<2> is lower alkyl, (substituted) aryl, or aralkyl], -CH2OR<2>, or -CH2OCOR<3>[R<3> is H, lower alkyl, (substituted)aryl, or aralkyl)}, and its salt. EXAMPLE:(1R)-2-( 4-Hydroxyphenyl )-1-{N-[(1S,2S)-methoxycarbonyl-2-methylbutyl] carbamoyl-L-tyrosyl}aminoethylphosphonic acid. USE:An inhibitor against an enzyme capable of converting angiotensin, or an antihypertensive. PREPARATION:A compound shown by the formula II(X' is X or protected COOH or amino) is condensed with a compound shown by the formula III (Y is phenolic OH-protecting group; Z is lower alkyl) to give a compound shown by the formula IV, and the protecting groups Y and Z are eliminated.</p> |
