发明名称 |
IMPROVED PROCESS FOR THE SILYLATION OF ORGANIC COMPOUNDS WITH 1,1,1-TRIMETHYL-N-(TRIMETHYLSILYL)SILANAMINE BY MEANS OF CATALYSIS WITH CERTAIN NITROGEN CONTAINING COMPOUNDS |
摘要 |
An improved process for the trimethylsilylation of organic compounds with at least one active hydrogen atom with hexamethyldisilazane, the improvement comprising effecting the reaction in the presence of 0.001 to 10 mole percent of a catalyst of the formula X-NH-Y I wherein X and Y are individually an electron-withdrawing group or when X is an electron-withdrawing group, Y is selected from the group consisting of hydrogen and trialkylsilyl of 1 to 6 carbon atoms or X and Y together with the nitrogen atom to which they are attached form a cyclic electron-withdrawing group and novel trimethylsilylated thiols of the formula <IMAGE> wherein R is a 5-or 6-membered heterocycle having at least one nitrogen or sulfur heteroatom and optionally substituted with at least one member of the group consisting of alkyl of 1 to 6 carbon atoms, phenyl, trimethylsilyl, trimethylsilyloxycarbonylmethyl and alkylamino of 1 to 6 carbon atoms, and novel trimethylsilylated 3'-substituted cephalosporanic acid derivatives. |
申请公布号 |
DE3173428(D1) |
申请公布日期 |
1986.02.20 |
申请号 |
DE19813173428 |
申请日期 |
1981.07.03 |
申请人 |
GIST - BROCADES N.V. |
发明人 |
BRUYNES, CORNELIS ADRIANUS;JURRIENS, THEODORUS KLAAS |
分类号 |
C07D499/00;C07D499/12;C07D501/04;C07D501/06;C07F7/08;C07F7/10;C07F7/18;C07F9/24;C07H23/00;C07J51/00;(IPC1-7):C07F7/08 |
主分类号 |
C07D499/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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