发明名称 |
MELLANPRODUKTER, 1-OXADETIACEFAM-FORENINGAR SAMT FORFARANDE FOR FRAMSTELLNING DERAV |
摘要 |
Intermediates for preparing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: <IMAGE> wherein R is a monovalent group (minus the carbonyl) from an acyl group derived from a carboxylic or carbonic acid; Y1 is a divalent group of the following formula: <IMAGE> +TR <IMAGE> wherein COB is carboxy or protected carboxy; X is hydrogen or a nucleophilic group; and Z is a leaving group are prepared from a compound of the following formula: <IMAGE> wherein R and Y1 are as defined above by the action of an acid. The new compounds of this invention shown by the following formula: <IMAGE> wherein A is amino or substituted amino; E is hydrogen or methoxy; and Y is a divalent group of the following formula: <IMAGE> in which COB, X, and Z are as defined above are convertible into other compounds of the same formula by applying conventional methods in beta -lactam chemistry. |
申请公布号 |
SE443144(B) |
申请公布日期 |
1986.02.17 |
申请号 |
SE19780001697 |
申请日期 |
1978.02.14 |
申请人 |
SHIONOGI & CO LTD |
发明人 |
1)M * YOSHIOKA;2)S * UYEO;3)Y * HAMASHIMA;4)I * KIKKAWA;5)T * TSUJI;6)W * NAGATA |
分类号 |
C07D498/04;C07D505/00;(IPC1-7):C07D498/04 |
主分类号 |
C07D498/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|