| 摘要 |
PURPOSE:To obtain industrially, advantageously and continuously the titled compound, by bringing an aqueous layer produced from the water washing step into contact with acetophenone, mixing the resultant oil layer in the reaction solution to be fed to the water washing step to obtain the titled compound from the above-mentioned compound and phenol in the presence of a specific catalyst. CONSTITUTION:Acetophenone (D) is reacted with phenol (A) in the presence of a metal chloride catalyst and/or hydrogen chloride catalyst (B) to synthesize the titled compound in a reaction vessel 1, and the reaction solution 8 is washed with water in a water washing vessel 2 and separated into an oil layer 10 and aqueous layer 12 in a liquid separation tank 3. The resultant oil layer 10 is then distilled in a distillation column 4 to return the resultant distillate 11 to the synthesis step 1. The bottom product 13 is recrystallized to prepare continuously the titled compound (F). In the process, the above-mentioned aqueous layer 12 is brought into contact with the raw material (D) at 10-50 deg.C and extracted in an extraction vessel 5. The resultant oil layer 7 is mixed in the above-mentioned reaction solution 8 to carry out easily and efficiently the removal of the catalyst in the water washing step 2 and improve the yield of the aimed compound at the same time. The operating temperature of the water washing step is >=60 deg.C, and the amount of the water to used for water washing is 50-200pts.wt. based on 100pts.wt. mixture of the reaction solution 8 with the oil layer 7. |
