发明名称 |
Process for preparing substituted pyrimidinones |
摘要 |
This invention provides a process for the preparation of pyrimidinone compounds with a group R2CH(OH)- at the 5-position thereof, wherein R2 is an optionally substituted acid-stable 5- or 6-membered nitrogen-containing heteroaryl group. The pyrimidinone ring is further substituted by a side-chain of a H1-antagonist or H2-antagonist or a precursor thereof. The compounds are convertible to 5-heteroaryl methyl compounds which are either useful H1- or H2-antagonists or precursors thereof.
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申请公布号 |
US4569996(A) |
申请公布日期 |
1986.02.11 |
申请号 |
US19830517543 |
申请日期 |
1983.07.27 |
申请人 |
SMITH KLINE & FRENCH LABORATORIES LIMITED |
发明人 |
KITTERINGHAM, JOHN;SLINGSBY, BRIAN P. |
分类号 |
C07D239/46;C07D401/14;(IPC1-7):C07D239/02 |
主分类号 |
C07D239/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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