Amidine compound, process for producing same and anti-complement agent comprising same

摘要

Amidino compounds represented by the formula <IMAGE> (I) and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsine, anti-plasmin, anti-kallikrein and anti-thrombin agents. Having strong anti-Cl (Cl &upbar& r, Cl &upbar& s) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II) R1-COOH (II) with amidinophenol compound (III) and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof. <IMAGE> (III)