发明名称 Derivatives of N-[2-(tetrahydro-3,5-dioxo-1H-pyrrolizin-7a(5H)-yl)ethyl]amine.
摘要 <p>A compound having the following general formula I: &lt;CHEM&gt; wherein A is the radical -NR1R2 in which R1 and R2 are independently hydrogen, lower alkyl, or lower alkenyl; or wherein A is the radical -NHR3 in which R3 is phenyl, phenylmethyl, N,N-bis (1-methylethyl)- aminoethyl or 4-pyridyl; or wherein A is the radical -OR4 in which R4 is lower alkyl, phenyl (optionally substituted in the 2-, 3-, or 4-position with one or more of a chlorine, fluorine, lower alkoxy or phenylmethoxy), or phenylmethyl (optionally substituted in the 2-,3-, or 4- position with one or more of a chlorine, fluorine, lower alkoxy or phenyl (methoxy); and the pharmaceutically acceptable salts of those compounds of formula I having a basic nitrogen atom. The compounds are effective as cognition activators for treating senility or for reversing the effects of electroshock induced amnesia. A process for producing the compounds, a useful intermediate in their preparation and pharmaceutical compositions are also disclosed. </p>
申请公布号 EP0170460(A1) 申请公布日期 1986.02.05
申请号 EP19850305022 申请日期 1985.07.15
申请人 WARNER-LAMBERT COMPANY 发明人 BUTLER, DONALD E.;LEONARD, JAMES D.
分类号 C07D487/04;(IPC1-7):C07D487/04;A61K31/40 主分类号 C07D487/04
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