Nitrosothiol derivatives, their production and use.

摘要

Novel nitrosothiol derivatives of the formula: <CHEM> wherein R<1> and R<2> are independently a hydrogen atom or a hydrocarbon residue which may be substituted; R<3> is a hydrogen atom, an acyl group or a hydrocarbon residue which may be substituted; X<1> is a hydrogen atom, an acyl group, a lower alkoxy group or a hydrocarbon residue which may be substituted; X<2> is an acyl group or a carboxyl group which may be esterified or which may form an amide; with a proviso that when X<2> is a carboxyl group X<1> is not a hydrogen atom or acetyl group and that when both R<1> and R<2> are hydrogen atoms X<1> is not an acetyl group or gamma -glutamyl group, and salts thereof, show excellent hypotensive action, anti-arrhythmic action, anti-anginal action, cardiotonic action or coronary vasodilation, thus being useful as therapeutic or prophylactic agents for the cardiovascular diseases such as hypertension and angina pectoris.