| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is (protected) amino; R<2> is H, (substituted) phenyl, heterocyclic group, alkyl, cycloalkyl, (esterified) carboxyl or halogen; R<3> is H or lower alkyl; R<4> is H or methoxy] or its salt. EXAMPLE:3-[2-( 2-Aminothiazol-4-yl )-2-benzylideneacetamido]-4-methyl-2-azetidinone-1-sulfonic acid. USE:Preventive and remedy for bacteriosis. PREPARATION:The objective compound can be prepared by reacting 3-amino-2- azetidinone-1-sulfonic acid of formula II or its reactive derivative at the amino group or their salts with the compound of formula III or its reactive derivative at the carboxyl group or their salts, in an inert solvent preferably at 0-40 deg.C. |
