| 摘要 |
<p>17 alpha -bromo- alpha and 17 alpha -iodo-vinyl-estrane derivatives of general formula I <IMAGE> (I) wherein X is a bromine or iodine atom in Z or E position, R1 is hydrogen, hydroxy or acyloxy with up to 3 C atoms, R2 is hydrogen, alkyl with up to 3 C atoms and alkanoyl and aroyl with up to 7 C atoms, R3 is hydrogen or methyl, R4 is a hydrogen atom in the alpha or beta position, R5 is hydrogen, methyl or methoxy and R6 is hydrogen or methyl, are pharmacologically effective with a profile of action like ethinylestradiol and in the form of their radioactively labeled compounds are also valuable diagnostic media. The Z-isomers can be prepared by a new process by reaction of the corresponding 17 alpha -ethinyl steroids with trialkyl (or phenyl) tin hydride with addition of a free radical former.</p> |
