| 发明名称 |
TYROSINE PHOSPHORYLATION IN PROTOZOANS |
| 摘要 |
A method for the treatment of microbial-induced disorders such as the protozoabased diseases malaria and leishmania is described in which the phosphorylation of tyrosine residues in proteins is modulated. Specific phosphorylation of trypanosomal proteins, in T.brucei, is disclosed. Tyrosine kinase and tyrosine phosphatase inhibitors are disclosed for administration to patients in the treatment method of the described invention.
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| 申请公布号 |
CA2064550(A1) |
申请公布日期 |
1992.10.02 |
| 申请号 |
CA19922064550 |
申请日期 |
1992.03.31 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY;SEATTLE BIOMEDICAL RESEARCH INSTITUTE |
发明人 |
PARSONS, MARILYN;LEDBETTER, JEFFREY A.;SCHIEVEN, GARY L. |
| 分类号 |
A61K33/24;A61K31/275;A61K31/35;A61K33/00;A61K45/00;A61P33/00;A61P33/02;(IPC1-7):A61K33/24 |
主分类号 |
A61K33/24 |
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