发明名称 |
N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B |
摘要 |
As new semi-synthetic antibiotic derivatives are provided N-methanesulfonic acid derivatives of 3-demethoxyistamycin B which are less toxic than the parent 3-demethoxyistamycin B but retain usefully high antibacterial activity of the parent antibiotic. The new derivatives are produced by a method of N-sulfomethylation where 3-demethoxyistamycin B is reacted with an aldehyde such as paraformaldehyde and sulfurous acid or sulfite reagent.
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申请公布号 |
US4567165(A) |
申请公布日期 |
1986.01.28 |
申请号 |
US19840608213 |
申请日期 |
1984.05.08 |
申请人 |
MICROBIAL CHEM RES FOUND |
发明人 |
UMEZAWA, HAMAO;KONDO, SHINICHI |
分类号 |
C07H15/224;(IPC1-7):A61K31/71;C07H15/22 |
主分类号 |
C07H15/224 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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