| 摘要 |
PURPOSE:In production of the titled substance by cultivating a bacterium, to improve fermentation yield and accumulation, by using a bacterium belonging to the genus Brevibacterium or Corynebacterium, having alpha-ketomalonic acid resistance. CONSTITUTION:A bacterium belonging to the genus Brevibacterium or Corynebacterium, such as Brevibacterium lactofermentum, Corynebacterium glutanicum, etc., capable of producing L-glutamic acid is subjected to variation and induction, to collect a strain having alpha-ketomalonic acid resistance. Prepared Brevibacterium flavum AJ12152, Corynebacterium glutamicum AJ12153, etc. is cultivated, and L-isoleucine is collected from the medium. |
