Monoclonal antibodies directed against the cellular receptor of human rhinovirus.

摘要

DNA fragments encoding all the structural and non-structural proteins and untranslated RNA genome regions of humanrhinovirus type 14 have been molecularly cloned and their nucleotide sequence determined. The composition and sequence of the entire 7,212 nucleotide long genome RNA have been determined. Monoclonal antibodies have been produced which block the binding of virus to susceptible cells or which neutralize the infectivity of the virus.