Inhibitors of slow reacting substance of anaphylaxis.

摘要

Novel compounds (and their pharmaceutically acceptable salts) and compositions which inhibit slow reacting substance of anaphylaxis in mammals are disclosed, together with methods for preparing said compounds and compositions and methods for their use for treating psoriasis, allergic reactions and inflammation and for reducing the severity of myocardial infarction resulting from heart attack. The novel compounds are of the formula A <CHEM> wherein Z and Z<1> are W-X or Y where W is O, S, SO or SO2; T is 7-15 alkyl; X is a 2-12 C divalent hydrocarbon group which may be substituted with the group -NHR<a>; Y is 1-12 C alkylene; where T, X and Y can each contain 1-3 non-cumulative double or triple bonds; U is -CH2CH2-, -CH=CH- or -C IDENTICAL C-; V is 1-4 C alkylene or a direct bond; R<2> and R<3> are hydrogen, CH2OR<c>, CHO, 2-tetrazolyl, COR<d> or SO3H, at least one of R<2> and R<3> being 2-tetrazolyl or carboxyl; and R is hydrogen or, where Z and Z<1> are both W-X, R can also be stright or branched chain alkyl having from 1 to 6 carbon atoms, or where Z and Z<1> are both Y, R can also be hydroxy or fluorine or can be combined with Z and with the mutually bonded carbon atom to form a C-Z double bond or a cyclo-propane ring.