发明名称 |
REAGENTS AND METHODS FOR THE DETECTION OF METHOTREXATE |
摘要 |
A murine monoclonal IgG antibody is provided which is useful in the detection of methotrexate in body fluids. This monoclonal antibody, designated 4-351-178, may be employed in an assay for methotrexate, preferably a fluorescence polarization immunoassay (FPIA) of urine. Monoclonal antibody 4-351-178 is characterized by having no detectable cross-reactivity with 7-hydroxymethotrexate. Also disclosed is a hybridoma cell line, ATCC HB 11467, which produces the monoclonal antibody of the invention.
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申请公布号 |
CA2178590(A1) |
申请公布日期 |
1995.06.15 |
申请号 |
CA19942178590 |
申请日期 |
1994.11.22 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
TYNER, JOAN D.;JUVELAND, SHERRI L. |
分类号 |
G01N33/53;C07K16/44;C12N5/00;C12N5/10;C12N5/20;C12N15/02;C12P21/08;C12R1/91;G01N33/533;G01N33/577;G01N33/94;(IPC1-7):C12N5/18 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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