| 摘要 |
Novel indoloquinoxalines having substituents in 6-position containing cyclic groups, of the general formula I
<CHEM>
wherein R1 represents hydrogen or one or several preferably 1 to 4, similar or different substituents in the positions 1-4 and/or 7-10, selected from halogen, lower alkyl-/alkoxy group having not more than 4 carbon atoms, trifluoromethyl group, trichloromethyl group;
X is a group
<CHEM>
wherein Y is CH2, NH, O or S and a is 2, 3 or 4 and wherein also the bond -C=N- can be saturated; Z is alkyl having 1-6 carbon atoms, Cl, Br or CF3 and
R3 represents hydrogen, lower alkyl-/cykloalkyl group having not more than 4 carbon atoms,
and the physiologically acceptable addition products of the compounds with acids and halogen adducts are described. Also methods for preparing said compounds by reaction of a compound of the formula II
<CHEM>
with a reactive compound containing the residue -CHR3X or by rearranging a compound of the formula III
<CHEM>
by heating, are described.
<??>The novel indoloquinoxalines have antiviral effect and have effect against cancer. |
