发明名称 |
Dicarbamates |
摘要 |
Novel pyrimidinedicarbamates of the formula <IMAGE> I wherein R is lower alkyl or (lower alkyloxy)-(lower alkyl) and X is a leaving group, can be manufactured by carbamoylating the corresponding free diamines. They are valuable intermediates and can be used, for example, for the manufacture of corresponding oxadiazolopyrimidines of the formula <IMAGE> II and pharmaceutically acceptable salts thereof. The latter have valuable long-lasting vasodilating and/or bloodpressure lowering properties and are accordingly suitable especially for the treatment of vascular-conditioned hypertensions or as vasodilators in the case of peripheral blood supply disorders.
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申请公布号 |
US4565869(A) |
申请公布日期 |
1986.01.21 |
申请号 |
US19830472696 |
申请日期 |
1983.03.07 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
IMFELD, MARQUARD;RAMUZ, HENRI;VOGT, PETER;MULLER, JEAN-CLAUDE |
分类号 |
C07D239/48;C07D401/04;C07D498/04;(IPC1-7):C07D239/48 |
主分类号 |
C07D239/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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