| 摘要 |
1. Pyrimidine derivatives of the formula : …<CHEM>… wherein… Ar is aryl substituted with 1 to 3 substituent(s) selected from the group consisting of nitro, amino, halogen, cyano, hydroxy, carbamoyl, halo(lower)-alkyl, lower alkoxy, halo(lower) alkoxy, lower alkanoyloxy, lower alkylthio, lower alkanesulfinyl, lower alkanesulfonyl, esterified carboxy, optionally substituted N-containing heterocyclic group and a group of the formula : …<CHEM>… (in which X, l , R<4>, R<5> and R<6> are each as defined in the below) or heterocyclic group containing one nitrogen and/or sulfur atom(s) and optionally substituted with nitro or halogen substituent(s);… R<1> is carboxy, esterified carboxy, lower alkanoyl, cyano, amino, carboxyamino, esterified carboxyamino, a group of the formula :… R<7> and R<8> are taken together to form an optionally substituted N-containing heterocylic group with the adjacent nitrogen atom; provided that the substituent(s) on the aryl group for Ar is not halogen when R<2> is hydrogen; and the pharmaceutically acceptable salts thereof. …<??>The pyrimidine derivates disclosed are useful in the treatment of cerbrovascular diseases. |
