| 摘要 |
<p>Disclosed are compounds of formula I <IMAGE> (I) wherein Ar is 3- or 4-pyridyl or 3- or 4-pyridyl substituted by lower alkyl; R1 is hydrogen, halogen, trifluoromethyl, lower alkyl, hydroxy, acylated or etherified hydroxy, lower alkyl-(thio, sulfinyl or sulfonyl), or two of R1 on adjacent carbon atoms represent alkylenedioxy; p is 1 or 2; R2 represents hydrogen or lower alkyl; one of R3 and R4 represents hydrogen and the other of R3 and R4 represents the group A-B in which A represents alkylene of 1 to 12 carbon atoms, alkynylene or alkenylene of 2 to 12 carbon atoms each, lower alkylene-phenylene, lower alkylene-(thio or oxy)-lower alkylene, lower alkylene-(thio or oxy)-phenylene, lower alkylenephenylene-lower (alkylene or alkenylene), or alkadienylene or 4 to 12 carbon atoms; and B represents carboxy, esterified carboxy, carbamoyl, mono- or di-lower alkylcarbamoyl, cyano, hydroxycarbamoyl, or 5-tetrazolyl; the pyridyl-N-oxides thereof; and pharmaceutically acceptable salts thereof; methods for their synthesis and pharmaceutical compositions thereof. These compounds are useful as selective thromboxane synthetase inhibitors for the treatment of diseases such as cerebral ischaemia, shock, thrombosis and ischaemic heart disease.</p> |
