发明名称 |
GENETICALLY ENGINEERING E. COLI LT-B ENTEROTOXIN SUBUNIT |
摘要 |
Methods and compositons are provided for the cloning and expression of genes coding for the non-toxic subunit of the heat-labile enterotoxin (LT-B) of E. coli. The LT-B thus produced may be formulated for use as an immunogen in vaccines. Specific antibodies produced by this invention may be used in diagnostic tests for the detection of Vibrio cholerae or LT positive enterotoxigenic E. coli. The antibodies of this invention may further be formulated into passive vaccines for the prophylactic or therapeutic protection of human beings or other mammalian species against diarrheal diseases caused by Vibrio cholerae or by the LT positive enterotoxigenic E. coli or other bacteria. |
申请公布号 |
AU4458785(A) |
申请公布日期 |
1986.01.16 |
申请号 |
AU19850044587 |
申请日期 |
1985.07.04 |
申请人 |
PRAXIS BIOLOGICS INC. |
发明人 |
JOHN D. CLEMENTS |
分类号 |
A61K39/108;C07K1/22;C07K14/00;C07K14/195;C07K14/245;C07K14/28;C07K14/41;C07K16/00;C07K16/12;C12N1/20;C12N15/00;C12N15/09;C12P21/00;C12P21/08;C12R1/19;C12R1/91;G01N33/569;G01N33/577 |
主分类号 |
A61K39/108 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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