发明名称 1-HYDROXYCYTORHODINES, A MICROBIOLOGICAL PROCESS FOR THEIR PREPARATION, AND THEIR USE AS CYTOSTATICS
摘要 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.
申请公布号 AU4473485(A) 申请公布日期 1986.01.16
申请号 AU19850044734 申请日期 1985.07.09
申请人 HOECHST A.G. 发明人 WERNER ARETZ;HANS GERD BERSCHEID;HANS-WOLFRAM FEHLHABER;DIRK BOTTGER;HANS PETER KRAEMER
分类号 C07C50/36;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;C07C45/00;C07C67/00;C07H15/252;C12P19/56;C12R1/465 主分类号 C07C50/36
代理机构 代理人
主权项
地址