发明名称 |
TISSUE PLASMINOGEN ACTIVATOR GLYCOSYLATION VARIANTS WITH IMPROVED THERAPEUTIC PROPERTIES. |
摘要 |
<p>The invention concerns tissue plasminogen activator (t-PA) variants which are glycosylated at any of positions 103-105, and are devoid of functional carbohydrate structure at position 117 of wild-type human t-PA amino acid sequence. The variants have extended circulatory half-life and substantially retained fibrin binding, or improved in vivo fibrinolytic potency, as compared to wild-type human t-PA. <IMAGE></p> |
申请公布号 |
GR3024806(T3) |
申请公布日期 |
1998.01.30 |
申请号 |
GR19970402440T |
申请日期 |
1997.09.22 |
申请人 |
GENENTECH, INC. |
发明人 |
BENNETT, WILLIAM, F.;KEYT, BRUCE, ALAN;PAONI, NICHOLAS, F. |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61P7/02;C12N9/64;C12N9/72;C12N15/58;C12R1/19;(IPC1-7):C12N15/58;C12N5/10;A61K38/48 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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