BENZAMID-DERIVATE.

摘要

Benzamides of the formula wherein R<1> and R<2> each independently signify hydrogen, halogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, sulphamoyl, mono(lower alkyl)sulphamoyl or di(lower alkyl)sulphamoyl or R<1> and R<2> on adjacent carbon atoms together signify a methylenedioxy group, with the proviso that R<2> is different from hydrogen when R<1> signifies bromine in the 3-position, and their pharmaceutically usable acid addition salts have interesting monoamine oxidase inhibiting properties with low toxicity and can accordingly be used for the treatment of depressive states and Parkinsonism. Those compounds of formula I in which R<1> signifies halogen, cyano or trifluoromethyl in the para-position and R<2> signifies hydrogen or R<1> and R<2> together signify 2,4-dichloro, 3,4-dichloro or 3,4-methylenedioxy are novel; these novel compounds can be manufactured according to methods known per se.