| 摘要 |
NEW MATERIAL:The compound of formula I (R1 is CH=CH2, group of formula II, formula III, etc.; R2 is CH3, CHO or CH2OH; R3 is C=O, OH or OCOCH3; R4 is H, COOCH3, COONH, etc.; R5 is COOH, COONa, or COOCH3) and its alkali metal salt. Excluding phaeophorbide, 9-desoxo-9-hydroxy-phaeophorbide and pyrophaeophorbide. EXAMPLE:2-Desethenyl-2-(1-hydroxyethyl)-9-desoxo-9-hydroxy-phaeophorbide. USE:A photo-sensitizer for the remedy of cancer. PREPARATION:The compound of formula I can be prepared by treating phaeophorbide with hydrobromic acid, and reducing an acetylating the resultant 2- desethenyl-2-(1-hydroxyethyl)-phaeophorbide. |
