| 摘要 |
PURPOSE:To produce the titled compound, by reacting a specific azetidinone compound with a compound such as triethyl phosphite, and cyclizing the obtained compound. CONSTITUTION:The 1-substituted carbapenem-3-carboxylic acid derivative of formula III (e.g. the compound of formula IV) can be prepared by reacting the compound of formula I [R<1> and R<2> are H (at least one of which is not H), alkyl, alkenyl, alkynyl, aryl, aralkyl or R<1> and R<2> together form a ring, etc.; R<3> is alkyl, aralkyl, heteroalicyclic group, aryl, aromatic heterocyclic group, etc.; R<4> is carboxyl-protecting group; R<5> is H or OH-protecting group] with the compound of formula P(R<6>)3 (R<6> is alkoxy, aryloxy or dialkylamino), and cyclizing the resultant compound of formula II. |
