| 摘要 |
There are described compounds of formula I, <CHEM> in which Rc is a nucleophilic nitrogen, oxygen or sulphur separated from the SO group by 1, 2, 3, 4 or 5 other atoms, R1, R2,R3 and R4, which may be the same or different, are each hydrogen, halogen, alkoxy, alkyl, fluoroalkyl, alkanoyl, RS(O)n-, -NO2, -N(R)2, -NHCOR, or -COOH or an ester or amide thereof, or an adjacent pair of R1, R2, R3 and R4 may in addition to the values given above, together form a chain -(CH2)x- or, together with the carbon atoms to which they are attached, form a 6 membered unsaturated carboxylic or nitrogen heterocyclic ring, x is 3, 4 or 5, n is 0, 1 or 2, X is O, S or NR15, R15 is hydrogen, -COR, -COOR or alkyl which latter is optionally substituted by -OCOR, R is phenyl, or alkyl optionally substituted by phenyl, the phenyl groups in turn optionally being substituted by alkyl, provided that i) Rc is not -CH2CH2-morpholino, ii) that when Rc is a nitrogen nucleophile carried on an aryl or heteroaryl group R15 is not a group -COR in which R is unsubstituted alkyl, iii) when X is NR15 Rc does not comprise an unsaturated nitrogen heterocyclic ring other than such a ring substituted by a either a) a substituted or unsubstituted amino group, or b) an N-oxido group, and iv) when X is NR15 Rc does not comprise an alkyl group substituted by an optionally alkyl or halo substitute piperidino group, and pharmaceutically acceptable salts thereof. There are also described processes for making the compounds, and their formulation and uses as pharmaceuticals, e.g. to treat gastric acid secretion. |
