NOVEL PHENYLALKYLAMINOALCOHOL CARBAMATES AND PROCESS FOR PREPARING THE SAME

摘要

PCT No. PCT/KR95/00114 Sec. 371 Date Jul. 1, 1996 Sec. 102(e) Date Jul. 1, 1996 PCT Filed Sep. 6, 1995 PCT Pub. No. WO96/07637 PCT Pub. Date Mar. 14, 1996O-carbamoyl-(D/L )-phenylalaninol represented by structural formula I is pharmaceutically useful to treat diseases of the central nervous system, which is prepared by a characteristic process comprising the steps of: treating phenylalaninol with benzyl chloroformate in a basic aqueous solution medium, to give N-benzyloxycarbonyl-phenylalaninol; subjecting this intermediate to reaction with phosgene and then, to the treatment with excess of concentrated ammonium hydroxide aqueous solution, to provide O-carbamoyl-N-benzyloxycarbonyl-phenylalaninol; deprotecting it through hydrogenolysis reaction.