PREPARATION OF INFUSION GRADE WATER

摘要

An apparatus is disclosed for the preparation of infusion grade water for use in the preparation of parenteral solutions. The apparatus is comprised of a two component system including a chemical purification unit and an endotoxin filter receiving assembly (80). Chemical purification of the water is achieved by treating the feed water using a sequence of carbon adsorption, reverse osmosis, deionization, and membrane filtration. The chemically pure water from this system is used as a feed water to a low molecular weight cutoff membrane ultrafilter (82), which is an integral part of a presterilized manifold (90) with receiving bags (92). The receiving bags (92) may contain premeasured solutes in sterile nonpyrogenic powder form or in concentrated solution form to yield by dilution typical parenteral solutions ready for administration.